Category Archives: HIV

“All Adult HIV Patients Should Be Offered Antiretroviral Therapy”

by D Gregory Smith

From Science Daily:

Included in the 2012 International Antiviral Society-USA panel recommendations for human immunodeficiency virus (HIV) patient care is that all adult patients, regardless of CD4 cell count, should be offered antiretroviral therapy (ART), according to an article in the July 25 issue of JAMA, a theme issue on HIV/AIDS. Other new recommendations include changes in therapeutic options and modifications in the timing and choice of ART for patients with an opportunistic illness such as tuberculosis.

Melanie A. Thompson, M.D., of the AIDS Research Consortium of Atlanta, presented the findings of the article at a JAMA media briefing at the International AIDS Conference.

Journal of the American Medical Association

Journal of the American Medical Association (Photo credit: Wikipedia)

“Since the first antiretroviral drug was approved 25 years ago, improvements in the potency, tolerability, simplicity, and availability of ART have resulted in dramatically reduced numbers of opportunistic diseases and deaths where ART is accessible,” according to background information in the article. “New trial data and drug regimens that have become available in the last 2 years warrant an update to guidelines for ART in HIV-infected adults in resource-rich settings.”

The benefit of suppressing the virus, in my opinion, is greater than the possible toxicity of medication and navigating possible side effects. We know that as long as HIV is in the body, unchecked, it’s doing damage. It’s more likely than possible that people who start antiretroviral therapy early will have less problems with secondary conditions (joint pain, arthritis, memory problems) as they progress in their lives. I think this is tremendous news.

Full Story Here.

Related articles

President’s Welcome Video To International AIDS Conference 2012

by D Gregory Smith

Some history and a commitment to continue progress:

Related articles

HIV Treatment Breakthrough: Weekly Injection Could Replace Daily Pill Regimen

by D Gregory Smith
HIV-1 Gag

HIV-1 Gag (Photo credit: AJC1)

For a number of people with HIV, treatment can be troublesome because medicine should be taken at the same time every day- sometimes more than once a day. Some medications must be taken with food, some without. Some can only be taken near bedtime because they cause drowsiness.

Science Daily reports a treatment breakthrough:

(A) University of Nebraska Medical Center research team’s progress toward developing weekly or twice-monthly injectable antiretroviral therapy (ART) nanomedicines for patients with human immunodeficiency virus (HIV) infection will be highlighted as the cover story in the Journal of Infectious Diseases.

A long-acting, nanoformulated ART (nanoART) would be a substantive improvement over daily and sometimes more complex regimen of pills, said Howard Gendelman, M.D., the lead investigator on the development of nanoART for HIV/AIDS and professor and chairman of the department of pharmacology and experimental neuroscience (PEN) at UNMC.

The journal article hails the successful testing of UNMC’s ART injectables as treatment of HIV-infected mice and in preventing new infections.

“We actually followed the process exactly as we would with a person — and it worked,” Dr. Gendelman said. “This is all very exciting. Although there are clear pitfalls ahead and the medicines are not yet ready for human use, the progress is undeniable.”

This could prove to be helpful- most especially in the developing world- where people have trouble managing a regimen of pills or have low access to long-term medication treatments. But it may have significant impact everywhere, changing the way HIV is treated….

Full article here.

Related articles

Infographic: Ending The Drug War Will Help End AIDS

by D Gregory Smith

From Jag Davies, Drug Policy Alliance in today’s Huffington Post:

Throughout the world, research has consistently shown that drug criminalization forces people who use drugs away from public health services and into hidden environments where HIV risks become significantly elevated. Mass incarceration of nonviolent drug offenders also plays a major role in spreading the pandemic, as inhumane conditions and lack of HIV prevention or treatment measures in prison lead to HIV outbreaks and AIDS cases behind bars – and among families and communities once those imprisoned are released.

Yet in countries where addiction is treated as a health issue, the fight against HIV/AIDS is being won. New HIV infections in countries such as Australia, Germany and Switzerland have been virtually eliminated among people who use drugs, just as mother-to-child HIV transmission has been eliminated in countries that make medicines for pregnant women accessible.

In the United States, however, the federal government has resisted evidence-based HIV prevention strategies — costing us hundreds of thousands of lives and billions of dollars. Congress re-instated a longstanding ban last December that prohibits using federal funds for syringe access programs — a move that will cost thousands of more lives in years to come.

Money talks- just remind your politicians that the money they are not spending on “immorality” is costing the taxpayers 1000x the amount in the long run…

Guest Post: People Living with HIV Can Increase Physical Health and Quality of Life through Exercise

by D Gregory Smith

By Jim Rollince, GymSource

Adhering to a rigid exercise program can seem intimidating to a person who has been diagnosed with HIV.  Because this particular disease is so varied in how it affects each person who has it, people with HIV are often at various stages of physical health and emotional health.  Sometimes, the disease can seemingly lie dormant for years.  Other times, the disease can attack and leave a person feeling extremely ill, mentally depleted, and exhausted of nearly all energy.  Exercise is one way that a person who has HIV can fight back and take positive steps to regaining strength and increasing his or her overall health.

Increased Cardio Health Benefits Stem from Consistent Exercise Routines

It is well known that physical exercise can greatly improve cardio health.  In many situations, healthy hearts equal healthy bodies.  Many people are able to fight diseases through consistent exercise programs.  While beginning with a rigorous exercise program may not be feasible for an HIV patient who is fighting severe symptoms of the disease, beginning with a mild program and then steadily increasing it can result in wonderful improvements on the way the person feels each day.

Setting up home gym equipment is an ideal way to be prepared to exercise any time there is free time to do so.  If an HIV patient is working full time or part time, going to regular doctor visits, and taking care of other responsibilities, a home gym may be the best solution to find time to exercise.  Using a treadmill, an exercise bike, and an elliptical machine can result in tremendous health benefits and improved heart conditions.  Improving the heart and blood circulation throughout the body will make the person feel physically stronger and this can have a great and lasting impact on how well the person is physically able to cope with the disease.

Remain Committed to Regular Fitness Activities for Increased Health

The US National Library of Medicine provides an online medical journal that details numerous benefits that people who have been diagnosed with HIV or AIDS can gain from committing to regular exercise sessions.  Psychological benefits, increased circulation, easier breathing, and stronger muscles are all potential benefits a person can gain by committing to exercise on a regular basis.

Getting outside during nice weather and taking advantage of warm and pleasant weather to hike, swim, or go biking with friends is an ideal way to enjoy exercise and socialization at the same time.  When time is short, the individual can take advantage of fitness equipment at home to get in a few minutes of treadmill jogging or working out on an elliptical.  Every time a person engages in physical activity, the body will respond by increasing metabolism and potentially increasing levels of energy.

Note from Greg: Jim Rollince is a member of the creating writing department of Gym Source, a seller of home gym and training equipment including treadmills, ellipticals, bikes, arc trainers and more. He asked me if he could write about the importance of exercise in treating HIV, so I said “sure!”.

Exercise is important. This blog does not endorse any particular retail source for exercise equipment. However, a company that reaches out to people with HIV might deserve a second look….

Related articles

Truvada Approved For HIV Prevention

by D Gregory Smith
The first-ever daily pill to help prevent against HIV was approved Monday by U.S. regulators for use in uninfected adults who are at risk for getting the virus that causes AIDS.
Truvada, made by Gilead Sciences in California, has been on the market since 2004 and was approved by the Food and Drug Administration for a new use as a tool to help ward off HIV in otherwise healthy people, in combination with safe sex and regular testing.
The pill as pre-exposure prophylaxis has been hailed by some AIDS experts as a potent new tool against human immunodeficiency virus, but some health care providers are concerned it could encourage risky sex behavior.
In addition, the regimen is estimated to cost around $14,000 per year, making it out of reach of many.

The National Association of People With AIDS  (NAPWA) strongly supports today’s move by the United States Food and Drug Administration to approve use of Truvada (emtricitabine/ tenofovir disoproxil fumarate) for pre-exposure prophylaxis (PrEP) to reduce the risk of sexually acquired HIV-1 infection.

“It’s time for people at high risk of HIV infection to be empowered to protect themselves and others,” said Frank J. Oldham, Jr., NAPWA’s President and CEO. “Today’s approval of Truvada for HIV prevention gives them an important new tool to do that.

“PrEP is not a final solution to the spread of HIV,” Oldham continued, “but it can be one tool, and a very useful one, in a well stocked toolkit of prevention measures. We urge all Americans to assess their HIV risk realistically and use condoms if they are at risk, but we thank the FDA for approving Truvada for PrEP for those who cannot or will not.”

Truvada is one of the pills I take every day- if it can prevent anyone from getting HIV- it should. The “how” is still being determined.

 

Related articles

Reminder: AIDS Is Alive And Well In Montana

by D Gregory Smith

Kim McGeehan wrote an article for the Bozeman Magpie about HIV in Montana- and shared some of my story along the way. Excerpt:

English: HIV-1 particles assembling at the sur...

English: HIV-1 particles assembling at the surface of an infected macrophage. Français : Des particules de HIV-1 s’assemblant à la surface d’un macrophage infecté. (Photo credit: Wikipedia)

“I wasn’t diagnosed because I was scared. Now, I have memory issues and damage to my joints. HIV attacks soft tissues in the body—gums, brain, liver—even if you don’t have outward symptoms, the virus can still be doing damage,” Smith says. “At first, there were no treatments. Now there is a lot we can do. We can stop it or slow it down. You can live a healthy life. If you are on your meds and have a low viral load, your risk of transmitting the disease can be as low as 4%.”

That isn’t permission to take behavioral risks, but information that should encourage people to take advantage of the services offered by AIDS Outreach. Those services include fast, free, anonymous HIV tests, an HIV-positive support group, educational literature, and condoms condoms condoms.

Americans will soon be able to purchase an over-the-counter, rapid-response HIV test, but Smith worries that dealing with a positive result alone will be challenging for folks: “Denial is such a strong force in the human psyche. I remember it in myself. I’m worried that someone might test positive and not tell anyone, not get counseling or medical care.”

Read the rest:

http://www.bozeman-magpie.com/perspective-full-article.php?article_id=502

Related articles

AIDS Vaccine Possible Before End Of This Decade, HIV Scientist Says

by D Gregory Smith

From The New Civil Rights Movement:

HIV Particle

HIV Particle (Photo credit: AJC1)

A vaccine to protect against the Human Immunodeficiency Virus (HIV) and AIDS may be available before the end of this decade, a leading HIV research scientist says. RV144 may be the answer to fighting HIV/AIDS.

“We’re really working as fast as we can,” said Colonel Nelson Michael, director of the U.S. Military HIV Research Program at the Walter Reed Army Institute of Research, “who expects large-scale effectiveness studies to start in 2016,” according to a report in Reuters:

The hope is to have at least 50 percent effectiveness, a level that mathematical modelers say could have a major impact on the epidemic. Michael thinks this might be the pathway for getting the first HIV vaccine licensed, possibly by 2019.

Exciting news- Read the rest here

Related articles

United In Anger

by D Gregory Smith

I remember ACT UP as a bunch of people who would do anything to get AIDS seriously discussed by officials- hell by anybody. In the 80s and early 90s, gay men were often reviled as AIDS-infested refuse. ACT UP was founded to fight for their lives.

In his new movie, Jim Hubbard tells the story of the group. From The Hollywood Reporter:

Deutsch: Act Up Logo

Deutsch: Act Up Logo (Photo credit: Wikipedia)

Making a confrontational movement accessible without diluting its life-or-death message, Jim Hubbard‘s United in Anger: A History of ACT UP offers a straightforward biography of the activist group as seen from within its ranks.

In opening titles making a few stark assertions — 40,000 people died of AIDS in the U.S. between 1981 and 1987 (others sources offer different figures), a period during which Ronald Reagan couldn’t say the disease’s name in public — the film establishes both the immense fear within the gay community and the way that fear and anger attached itself to uninformed, foot-dragging, or oppositional politicians and institutions.

Following an onscreen timeline, the doc begins with Larry Kramer‘s call for a protest movement in 1987, using copious period footage to show how quickly New Yorkers took to the idea. Video shot in meetings and on the streets shows a movement that, in laser-guided messaging and organization, contrasts with some current protest movements — a comparison made inevitable as we hear one ACT UP member suggesting they take over an official building “by occupying it with our bodies.”

With chapters focusing on major demonstrations at the FDA, Wall Street, NIH and White House, the film charts the movement’s evolving mood and expanding agenda. If bystanders at the time saw them as mainly making a lot of noise, Hubbard and his many interviewees cite an impressive number of successes arising from these events; sped-up drug approvals, lowered pharmaceutical costs, and various bureaucratic victories, seen in hindsight, allow veteran activists to express satisfaction they couldn’t show while chanting accusations or being hauled out of sit-ins in handcuffs. They also acknowledge how central ACT UP meetings became to participants’ social lives, with some members attending meetings every night; in between the die-ins and agit-prop campaigns, we hear, “ACT UP was very sexy.”

Probably hard to watch- I can’t watch AIDS-era movies without a deep, overwhelming grief- but I will. We can’t afford to forget.

Related articles

AIDS Drug Assistance Program (ADAP) Watch 7/1/12

by D Gregory Smith

From NAPWA:

The waiting list numbers continue steady, just over 2,000, down from 9,000 in September of last year.

Coming off another National HIV Testing Day, we have to wonder how some states can encourage their citizens to get tested but not help them get lifesaving medicines if they test positive.

We also wonder what kind of cost analyses the waiting list states are doing. The cost of clearing the waiting lists completely just isn’t that great. Virginia has just under 600 PLWHA on its waiting list. If drugs cost $15,000 for one ADAP beneficiary for one year, drugs for 600 will cost $9 million – and we just don’t believe $9 million can’t be found in an $85 billion fiscal 2013 Virginia state budget. PLWHA on Virginia’s and other states’ waiting lists will cost the public sector a lot more if they don’t get drugs that can keep them from progressing to AIDS.

Here are the latest numbers from our friends at NASTAD:
Related articles